Thyroid Hormone Understanding Branches Out: Insights into PBDE Impacts on Brain Development

Understanding Branches Out Insights into PBDE Impacts on Brain Development Polybrominated diphenyl ether (PBDE) flame retardants and their hydroxylated metabolites are structurally similar to thyroid hormone. A detailed study now provides one of the most insightful assessments to date of how environmentally relevant levels of PBDEs may impair brain development by interfering with thyroid hormon...

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New insights into thyroid hormone replacement therapy

It is widely accepted that thyroid hormone replacement for patients with hypothyroidism can be fully accomplished with levothyroxine monotherapy, as assessed by serum thyroid function tests. However, approximately 10% of hypothyroid patients are dissatisfied with the outcome of levothyroxine monotherapy, and physicians continue to report benefits from combined levothyroxine-triidothyronine ther...

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Proteomic Insights into Brain Development: Neurotoxic Effects of PBDE-99 in Mice

Background: Relapse due to chemoresistant residual disease is a major cause of death in acute myelogenous leukemia (AML). The present study was undertaken to elucidate the molecular mechanisms of chemoresistance by comparing differential gene expression in blasts from patients with resistant relapsing AML and chemosensitive AML. Results: About 20 genes were identified as preferentially expresse...

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Beastly Beauty Products: Exposure to Inorganic Mercury in Skin-Lightening Creams

Understanding Branches Out Insights into PBDE Impacts on Brain Development Polybrominated diphenyl ether (PBDE) flame retardants and their hydroxylated metabolites are structurally similar to thyroid hormone. A detailed study now provides one of the most insightful assessments to date of how environmentally relevant levels of PBDEs may impair brain development by interfering with thyroid hormon...

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Heat Effects Are Unique: Mortality Risk Depends on Heat Wave, Community Characteristics

Understanding Branches Out Insights into PBDE Impacts on Brain Development Polybrominated diphenyl ether (PBDE) flame retardants and their hydroxylated metabolites are structurally similar to thyroid hormone. A detailed study now provides one of the most insightful assessments to date of how environmentally relevant levels of PBDEs may impair brain development by interfering with thyroid hormon...

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Thyroid Hormone Understanding Branches Out: Insights into PBDE Impacts on Brain Development

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